کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2586427 | 1130900 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Safety assessment of Lactobacillus brevis KB290 as a probiotic strain Safety assessment of Lactobacillus brevis KB290 as a probiotic strain](/preview/png/2586427.png)
Lactobacillus brevis KB290 (KB290), a plant-derived probiotic lactic acid bacterium, reportedly improves gut health and stimulates immune function. Here we extensively investigated the geno-, acute, subacute, and subchronic toxicity of KB290 and its bacterial translocation potential. KB290 was non-mutagenic in the bacterial reverse mutation assay by the preincubation method. In the single oral dose toxicity test, KB290 at ⩾109 cfu/ml was nontoxic at maximum capacity (20 ml/kg). When 108, 109, or 1010 cfu/kg was administered daily to rats by gavage for 2 weeks (subacute assay), we observed no clear treatment-related effect and no evidence of bacterial translocation from the gastrointestinal tract. When it was administered for 13 weeks (subchronic assay), we again observed no clear treatment-related effect and no significant toxicological effect. Based on those results, we consider 1010 cfu/kg per day, the highest dose tested, to be the no observed adverse effect level (NOAEL). These results suggest that KB290 is safe for human consumption.
Journal: Food and Chemical Toxicology - Volume 47, Issue 10, October 2009, Pages 2450–2453