کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2588517 1561900 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma polychlorinated biphenyls in residents of 91 PCB-contaminated and 108 non-contaminated dwellings—An exposure study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Plasma polychlorinated biphenyls in residents of 91 PCB-contaminated and 108 non-contaminated dwellings—An exposure study
چکیده انگلیسی

BackgroundIn the1950s–1970s polychlorinated biphenyls (PCBs) were used in several countries as plasticizers in elastic sealants in buildings.ObjectiveThe primary objective was to study whether residents of PCB-contaminated dwellings had higher plasma levels of PCBs than their neighbours in non-contaminated dwellings. The secondary objective was to study possible associations between concentrations of PCBs in the indoor air and in the plasma of residents.MethodsStratified cross-sectional study of residents of a housing estate with four sections, of which only one section had PCB-containing sealants. The determination of 27 PCB congeners in plasma was performed among 134 exposed and 139 non-exposed residents. Air measurements were conducted in 104 flats.ResultsSignificant differences in plasma PCBs between exposed versus non-exposed were found for most of the lower chlorinated and many of the higher chlorinated congeners. The median of sum of 27 PCBs was approximately four times higher in exposed compared with non-exposed residents. The elevated PCB concentrations persisted in multivariable analyses controlling for relevant cofactors. We found significant correlations between PCB indoor air concentrations and the PCB concentration in the plasma of the residents for ten of the lower chlorinated congeners.ConclusionOur study confirms that indoor air exposure to PCBs from PCB containing sealants may result in a considerable internal PCBs exposure of the residents. For the first time we were able to demonstrate that the internal exposure to low chlorinated PCBs is significantly associated with the indoor air concentration of these congeners.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Hygiene and Environmental Health - Volume 216, Issue 6, November 2013, Pages 755–762
نویسندگان
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