کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2588637 1561898 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects
ترجمه فارسی عنوان
قرار گرفتن در معرض آسیب های شغلی از قبیل سونوگرافی مادران و نقایص نامطلوب اسکلتی عضلانی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی

This population-based U.S. study investigated the association between major musculoskeletal malformations and periconceptional maternal occupational pesticide exposure for a wide range of occupations. We conducted a multi-site case–control analysis using data from the National Birth Defects Prevention Study among employed women with due dates from October 1, 1997 through December 31, 2002. Cases included 871 live-born, stillborn, or electively terminated fetuses with isolated craniosynostosis, gastroschisis, diaphragmatic hernia, or transverse limb deficiencies. Controls included 2857 live-born infants without major malformations. Using self-reported maternal occupational information, an industrial hygienist used a job-exposure matrix and expert opinion to evaluate the potential for exposure to insecticides, herbicides or fungicides for each job held during one month pre-conception through three months post-conception. Exposures analyzed included any exposure (yes/no) to pesticides, to insecticides only, to both insecticides and herbicides (I + H) and to insecticides, herbicides and fungicides (I + H + F). We used logistic regression to evaluate the association between exposures and defects, controlling for infant and maternal risk factors. Occupational exposure to I + H + F was associated with gastroschisis among infants of women aged 20 years or older (adjusted odds ratio [aOR] = 1.88; 95% confidence interval [CI]: 1.16–3.05), but not for women under age 20 (aOR = 0.48; 95% CI: 0.20–1.16). We found no significant associations for the other defects. Additional research is needed to validate these findings in a separate population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Hygiene and Environmental Health - Volume 217, Issues 2–3, March 2014, Pages 248–254
نویسندگان
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