کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2589079 1561923 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The capsaicin cough reflex in patients with symptoms elicited by odorous chemicals
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The capsaicin cough reflex in patients with symptoms elicited by odorous chemicals
چکیده انگلیسی

Patients with multiple chemical sensitivity and eczema patients with airway symptoms elicited by odorous chemicals have enhanced cough reflex to capsaicin when applying the tidal breathing method. The aims of the present study were to test whether the capsaicin induced cough reflex was enhanced when applying the single breath inhalation method in similar groups of patients with symptoms related to odorous chemicals e.g. other persons wearing of perfume; and to investigate to what extent the reporting of lower airway symptoms influenced the cough reflex.Sixteen patients fulfilling Cullen's criteria for multiple chemical sensitivity and 15 eczema patients with airway symptoms elicited by odorous chemicals were compared with 29 age-matched, healthy controls. We measured C5 – the capsaicin concentration causing five coughs or more – using the single breath inhalation test.No difference was found between groups in age, body mass index or pulmonary function. The median C5 were 129 μmol/L (control group), 48 μmol/L (multiple chemical sensitivity patients), 32 μmol/L (eczema patients). The reporting of lower airway symptoms from odorous chemicals was significantly (p<0.05) correlated to increased cough reflex sensitivity to capsaicin, independent of patient group or co-existence of asthma.The results suggest that the C5 is not reliable for diagnosing MCS but C5 can be used to verify presence of lower airway symptoms related to odorous chemicals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Hygiene and Environmental Health - Volume 213, Issue 1, January 2010, Pages 66–71
نویسندگان
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