کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2589868 | 1131712 | 2011 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring](/preview/png/2589868.png)
Manganese (Mn) and lead (Pb) exposures during developmental period can impair development by direct neurotoxicity or through interaction with iron metabolism. Therefore, we examined the effects of maternal ingestion of Mn or Pb in drinking water during gestation and lactation on iron metabolism as well as behavior in their offspring. Pregnant dams were given distilled water, 4.79 mg/ml Mn, or 2.84 mg/ml Pb in drinking water during gestation and lactation. Pups were studied at time of weaning for 59Fe absorption from the gut, duodenal divalent metal transporter 1 (DMT1) expression, hematological parameters, and anxiety-related behavior using an Elevated Plus Maze (EPM) test. Metal-exposed pups had lower body weights and elevated blood and brain concentrations of the respective metal. Pb-exposed pups had lower hematocrits and higher blood Zn protoporphyrin levels. In contrast, Mn exposed pups had normal hematological parameters but significantly reduced Zn protoporphyrin. Pharmacokinetic studies using 59Fe showed that intestinal absorption in metal-exposed pups was not different from controls, nor was it correlated with duodenal DMT1 expression. However, intravenously injected 59Fe was cleared more slowly in Pb-exposed pups resulting in higher plasma levels. The overall tissue uptake of 59Fe was lower in Mn-exposed and lower in the brain in Pb-exposed pups. The EPM test demonstrated that Mn-exposed, but not Pb-exposed, pups had lower anxiety-related behavior compared to controls. We conclude that gestational and lactational exposures to Mn or Pb differentially alter Fe metabolism and anxiety-related behavior. The data suggest that perturbation in Fe metabolism may contribute to the pathophysiologic consequences of Mn and Pb exposure during early development.
► Rat dams were exposed to Mn or Pb in drinking water during pregnancy and lactation.
► Mn and Pb maternal exposures altered iron metabolism and behavior in their offspring.
► These exposures reduced brain iron uptake contributing to their neurobehavioral effects.
Journal: NeuroToxicology - Volume 32, Issue 4, August 2011, Pages 413–422