کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2590016 | 1562061 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Late embryonic exposure to all-trans retinoic acid induces a pattern of motor deficits unrelated to the developmental stage
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Late embryonic exposure to all-trans retinoic acid induces a pattern of motor deficits unrelated to the developmental stage Late embryonic exposure to all-trans retinoic acid induces a pattern of motor deficits unrelated to the developmental stage](/preview/png/2590016.png)
چکیده انگلیسی
The present study extends previous investigations examining the behavioral outcomes of all-trans retinoic acid (RA) exposure at embryonic (E) days 14–16. A sublethal dose (2.5 mg/kg b.w.) compatible with high neonatal survival sufficient to supply offspring for later behavioral testing, was used. The results show that E14–16 RA exposure, similar to E8–10 or E11–13 (previous studies), impairs locomotor activity (open field test) as well as motor coordination and motor learning (rotarod/accelerod task) in young-adult rats. The results provide further evidence that RA exposure induces a pattern of motor deficits which are not strictly related to the embryonic stage, compatible with the protracted developmental profile of the cerebellum.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 30, Issue 6, November 2009, Pages 1120–1126
Journal: NeuroToxicology - Volume 30, Issue 6, November 2009, Pages 1120–1126
نویسندگان
Addolorata Coluccia, Pietro Borracci, Domenico Belfiore, Giuseppe Renna, Maria Rosaria Carratù,