کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2590080 1131723 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arsenic exposure disrupts neurite growth and complexity in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Arsenic exposure disrupts neurite growth and complexity in vitro
چکیده انگلیسی

Arsenic has neurotoxic effects on both central and peripheral components of the mature nervous system. There is increasing evidence that exposure to arsenic is also toxic to the developing nervous system and can result in decreased cell division and increased apoptosis in cultured developing neurons. However, the effects of arsenic on subsequent neuron growth and morphology remain unclear. In the present study we used differentiating PC12 cells to investigate the effects of sodium arsenite on the early stages of neurite production and growth. We find that arsenic has concentration- and time-dependent effects on initial neurite outgrowth in vitro. Exposure to low micromolar levels of sodium arsenite for five days results in reduced neurite production, outgrowth and complexity in newly differentiating PC12 cells. Furthermore, we find that exposure of more mature PC12 cells to arsenite can inhibit further neurite development. These results suggest that exposure to arsenic can disrupt early stages of neuron differentiation by altering the normal progression of morphological development and could potentially contribute to compromised long term functioning of neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 30, Issue 4, July 2009, Pages 529–537
نویسندگان
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