کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2590443 1131744 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of in vivo treatment with diphenyl ditelluride on the phosphorylation of cytoskeletal proteins in cerebral cortex and hippocampus of rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Effects of in vivo treatment with diphenyl ditelluride on the phosphorylation of cytoskeletal proteins in cerebral cortex and hippocampus of rats
چکیده انگلیسی

In this work, we investigated the effect of a single subcutaneous injection of diphenyl ditelluride (PheTe)2 in 15-day-old Wistar rats (0.3 μmol/kg body weight) on the phosphorylation of intermediate filament (IF) proteins in cerebral cortex and hippocampus, 1, 3 or 6 days after injection. Results showed that 3 and 6 days after injection with (PheTe)2, animals presented loss of body weight and cortical hyperphosphorylation of neurofilament subunits, glial fibrillary acidic protein (GFAP) and vimentin (Vim), the neuronal and glial intermediate filaments, respectively. Otherwise, in hippocampus, only GFAP and Vim were hyperphosphorylated and this effect was evidenced 6 days after injection. In cerebral cortex, hyperphosphorylation was accompanied by increased immunocontent of these proteins both in tissue homogenate and in cytoskeletal fraction, while in hippocampus only the immunocontent of cytoskletal-associated GFAP was increased. Moreover, hyperphosphorylation of cortical IF proteins, induced by (PheTe)2, was totally reversed by a single subcutaneous injection of diphenyl diselenide (PheSe)2 (5 μmol/kg body weight) 24 h after (PheTe)2 administration. Taken together, our results suggest that cortical cytoskeleton is more susceptible to (PheTe)2 than hippocampal cytoskeleton. Moreover, cytoskeletal dysfunction in cortical and hippocampal cells could be involved in the neurotoxicity induced by acute treatment with (PheTe)2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 29, Issue 1, January 2008, Pages 40–47
نویسندگان
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