کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2590816 | 1131782 | 2015 | 8 صفحه PDF | دانلود رایگان |
• This birth cohort study was established in New York City following collapse of the World Trade Center.
• We examined the relationship between prenatal exposure to PBDEs and attention problems measured throughout childhood.
• Median cord plasma PBDE levels ranged from 0.7–11.2 ng/g lipid.
• Prenatal PBDE exposure was associated with more attention problems at ages 3, 4 and 7 years.
IntroductionPolybrominated diphenyl ethers (PBDEs) comprise a class of halogenated compounds used extensively as flame retardant chemicals in consumer products resulting in nearly ubiquitous human exposure. Mounting evidence suggests that PBDEs are developmental neurotoxicants; however, associations between early life exposure and child behavior have been largely limited to a single developmental time point.MethodsThe study population consists primarily of white, black and Chinese women who were pregnant on 11 September 2001 and delivered at 1 of 3 downtown New York City hospitals. Maternal–child pairs were followed through age 7 years. Cord blood was collected at delivery and PBDE plasma levels for 210 samples were analyzed by the U.S. Centers for Disease Control and Prevention. The Child Behavior Checklist, a validated maternal-report instrument used for assessing child behavior, was administered annually between the ages of 3 and 7 years. We analyzed the association between natural log-transformed and dichotomized (low vs. high) PBDEs and attention problems using multivariable adjusted negative binomial regression.ResultsWe detected 4 PBDE congeners in more than 50% of samples, with concentrations highest for BDE-47 (median ± IQR: 11.2 ± 19.6 ng/g). In adjusted analyses, we detected associations between BDE-47 (1.21, 95% CI: 1.00, 1.47), and BDE-153 (1.18, 95% CI: 1.00, 1.39) in cord plasma and increased attention problems among children at age 4 (n = 109) but not 6 (n = 107) years.ConclusionsOur findings demonstrate a positive trend between prenatal PBDE exposure and early childhood attention problems, and are consistent with previous research reporting associations between prenatal PBDE exposure and disrupted child behaviors.
Journal: Neurotoxicology and Teratology - Volume 52, Part B, November–December 2015, Pages 143–150