The effects of a single memantine treatment on behavioral alterations associated with binge alcohol exposure in neonatal rats

► Developmental ethanol exposure induces hyperactivity, motor and learning deficits. ► NMDAR-mediated excitotoxicity during withdrawal may contribute neuropathology in FASD. ► NMDAR antagonists administered during withdrawal mitigate alcohol-related deficits. ► Memantine attenuates motor incoordination induced by developmental alcohol exposure.