Zebrafish as potential model for developmental neurotoxicity testing: A mini review

The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of zebrafish in toxicity research can ultimately lead to the refinement or reduction of animal use.

► Zebrafish as a multi-purpose model for investigating developmental toxicity.
► Embryonic, organ-based and behavioural toxicity screens are discussed.
► Enormous amount of data available for validation of this toxicity model.