کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2591780 1131827 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monoamine oxidase activity in placenta in relation to manganese, cadmium, lead, and mercury at delivery
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Monoamine oxidase activity in placenta in relation to manganese, cadmium, lead, and mercury at delivery
چکیده انگلیسی

BackgroundEnvironmental prenatal exposure to potentially neurotoxic metals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans.ObjectiveTo examine the relationship between blood metal concentrations at delivery and placenta MAO activity.MethodsThe study was performed in 163 pregnancies. Maternal and cord blood samples were obtained for manganese (Mn), lead (Pb), and cadmium (Cd) determination. Mercury (Hg) was also analysed in maternal hair. Placental samples were stored immediately after expulsion and total MAO activity was measured.ResultsMAO activity was significantly positively correlated with maternal and cord blood Mn concentrations in subjects with high MAO activity. In subjects with low MAO activity, maternal hair Hg was negatively correlated with MAO.ConclusionOur results suggest the use of placental MAO as a potential surrogate marker of Mn toxicity in the newborn and its correlation with psychomotor development should be further investigated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 32, Issue 2, March–April 2010, Pages 256–261
نویسندگان
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