کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2597404 | 1562412 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of tacrolimus on the cauda epididymis in rats: Analysis of epididymal biochemical markers or antioxidant defense enzymes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of tacrolimus on the cauda epididymis in rats: Analysis of epididymal biochemical markers or antioxidant defense enzymes Effect of tacrolimus on the cauda epididymis in rats: Analysis of epididymal biochemical markers or antioxidant defense enzymes](/preview/png/2597404.png)
چکیده انگلیسی
The effect of tacrolimus on epididymal biochemical markers was investigated following single daily subcutaneous doses of 1, 2 and 3 mg kgâ1 dayâ1 for 2 weeks to male adult rats. The tacrolimus 2 and 3 mg kgâ1 dayâ1 groups showed a significant and dose-dependent decrease in sperm count in the cauda epididymis. Among tissue levels of l-carnitine, α-glucosidase and acid phosphatase, only l-carnitine level in the cauda epididymis was significantly reduced in the tacrolimus 3 mg kgâ1 dayâ1 group. However, no significant difference was seen in the plasma l-carnitine. It was suggested that lowering of l-carnitine in the cauda epididymis was attributable to the adverse effect on epididymal function to transport and/or concentrate l-carnitine. Since l-carnitine has been reported to have antioxidant potential, antioxidant defense enzymes in the cauda epididymis such as superoxide dismutase (SOD), catalase, glutathion peroxidase and glutathione reductase were evaluated. The results showed no significant differences in activities, confirming that the treatment with tacrolimus did not affect the activities of these antioxidant enzymes. In conclusion, this study indicates that tacrolimus induces a decrease in l-carnitine level in the cauda epididymis, which is probably caused by impairment of epididymal function to transport and/or concentrate l-carnitine from bloodstream, and a decrease in sperm count.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 243, Issues 1â2, 14 January 2008, Pages 23-30
Journal: Toxicology - Volume 243, Issues 1â2, 14 January 2008, Pages 23-30
نویسندگان
Akihiko Hisatomi, Shozo Sakuma, Michio Fujiwara, Jiro Seki,