Keywords: AEDs; antiepileptic drugs; CNIs; calcineurin inhibitors; CsA; cyclosporine A; GABA; gamma aminobutyric acid; GTCS; generalized tonic-clonic seizure; MRI; magnetic resonance imaging; NAA; N-acetylaspartate; PRES; reversible posterior encephalopathy; SE; st
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Keywords: AUC; area under curve; C6; coumarin 6; CLSM; confocal laser scanning microscope; Cmax; the peak concentration; EDAC; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; FK506; tacrolimus; Gâ²; elastic modulus; Gâ³; viscous modulus; HA; hyaluron
Keywords: Atomic force microscopy; Tacrolimus; FK506; Label free
Keywords: Ischemic stroke; Liposomes; Middle cerebral artery occlusion; FK506; Neuroprotectants; Thrombolytic therapy;
Keywords: Immunophilin; FK506; FKBP; Cyclophilin; Cyclosporin; Redox;
Genome-wide transcriptome response of Streptomyces tsukubaensis to N-acetylglucosamine: effect on tacrolimus biosynthesis
Keywords: Streptomyces tsukubaensis; Tacrolimus; FK506; N-acetylglucosamine; Transcriptomics;
The effects of calcineurin inhibitor FK506 on actin cytoskeleton, neuronal survival and glial reactions after pilocarpine-induced status epilepticus in mice
Keywords: Status epilepticus; Pilocarpine; Filamentous actin; FK506;
Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model
Keywords: Surface modification; FK506; Islets transplantation; Local delivery; Diabetes mellitus;
Protective effect of Korean Red Ginseng against FK506-induced damage in LLC-PK1 cells
Keywords: FK506; Korean Red Ginseng; nephrotoxicity; MAPKs;
Reduction of FR900525 using an S-(2-aminoethyl) l-cysteine-resistant mutant
Keywords: FK506; FR900525; Streptomyces tsukubaensis No. 9993; S-(2-Aminoethyl) l-cysteine resistant; UV irradiation; Pipecolic acid; Lysine;
Targeted Inhibition of Pancreatic Acinar Cell Calcineurin Is a Novel Strategy to Prevent Post-ERCP Pancreatitis
Keywords: Adeno-Associated Virus; Calcineurin B1; FK506; Cyclosporine A; Intraductal Delivery; AAV; adeno-associated virus; Cn; calcineurin; CreERT2; Cre recombinase estrogen receptor T2; CsA; cyclosporine A; Ela; pancreatic elastase I; ERCP; endoscopic retrograde
Regular articleA genome-scale dynamic flux balance analysis model of Streptomyces tsukubaensis NRRL18488 to predict the targets for increasing FK506 production
Keywords: FK506; Tacrolimus; GS-DFBA; S. tsukubaensis NRRL18488;
An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat
Keywords: Tacrolimus; FK506; Retinal ganglion cell; CNS; Axon regeneration; Optic nerve;
FK506 protects heart function via increasing autophagy after myocardial infarction in mice
Keywords: Myocardial infarction; FK506; Autophagy; mTOR;
Diverse structures, functions and uses of FK506 binding proteins
Keywords: FK506; FK506 binding protein (FKBP); Immunophilin; Peptidylprolyl cis/trans isomerase;
Inhibition of senescence and promotion of the proliferation of chondrocytes from articular cartilage by CsA and FK506 involves inhibition of p38MAPK
Keywords: Senescence; p38MAPK; CsA; FK506; Chondrocyte;
Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates
Keywords: Susceptibility; FK506; Resistance; Synergism;
Peroxiredoxin 5 (Prx5) decreases LPS-induced microglial activation through regulation of Ca2+/calcineurin-Drp1-dependent mitochondrial fission
Keywords: TLR4; Toll-like receptor 4; NADPH oxidase; nicotinamide adenine dinucleotide phosphate oxidase; Cys; cysteine; Drp1; dynamin-related protein 1; Fis1; mitochondrial fission 1; Mfn1/2; mitofusin 1 and 2; Opa1; optic atrophy protein 1; Ser; serine; cAMP; Cyc
Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506
Keywords: Affinity resins; PEG; Target identification; Carbonic anhydrase II; FKBP12; Benzenesulfonamide; FK506; Calcineurin; Target complex
FKBPs and their role in neuronal signaling
Keywords: Neuroimmunophilin; FKBP51; FK506; Neurite outgrowth; Stress-related disorders;
FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease
Keywords: α-Synuclein; Parkinson's disease; FK506; Neuroinflammation; Microglia;
Insights into peptidyl-prolyl cis-trans isomerase structure and function in immunocytes
Keywords: PPIases; Immunophilins; CyPA; FKBP; Cyclosporine A; FK506;
FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6
Keywords: Cyps; cyclophilins; FKBPs; immunophilins; FKBD; FK506-binding domain; ER; rough endoplasmic reticulum; SERCA; sarco-endoplasmic Ca2+-ATPase; IP3Rs; inositol 1,4,5-trisphosphate receptors; IP3; inositol 1,4,5-trisphosphate; TRPC; transient receptor potenti
Crystal structures of resorcin[4]arene and pyrogallol[4]arene complexes with DL-pipecolinic acid. Model compounds for the recognition of the pipecolinyl ring, a key fragment of FK506, through C–H⋯π interaction
Keywords: Crystal structure; Pipecolinic acid; Resorcin[4]arene; Pyrogallol[4]arene; FK506; C–H⋯π interaction
FK506-loaded chitosan conduit promotes the regeneration of injured sciatic nerves in the rat through the upregulation of brain-derived neurotrophic factor and TrkB
Keywords: FK506; Chitosan; Nerve regeneration; BDNF; TrKB; Peripheral nerve injury
FK506 protects against articular cartilage collagenous extra-cellular matrix degradation
Keywords: Osteoarthritis; FK506; Cartilage matrix degradation; Osteoclastic subchondral bone resorption; Activation of synovial macrophages;
Co-stimulation with bone morphogenetic protein-9 and FK506 induces remarkable osteoblastic differentiation in rat dedifferentiated fat cells
Keywords: Dedifferentiated fat cells; BMP-9; FK506; Smad; Osteoblastic differentiation;
Expression analysis of XPhyH-like during development and tail regeneration in Xenopus tadpoles: Possible role of XPhyH-like expressing immune cells in impaired tail regenerative ability
Keywords: Tadpole tail regeneration; Refractory period; Autoimmune; Xenopus laevis; FK506; Phytanoyl-CoA dioxygenase;
FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway
Keywords: ANOVA; analysis of variance; bFGF; basic fibroblast growth factor; CsA; cyclosporin A; DMSO; dimethylsulfoxide; EGF; epidermal growth factor; eNOS; endothelial nitrogen oxide synthase; ERK; extracellular-regulated kinase; FKBP; FK506-binding protein; GAPD
The effects of 8-arm-PEG-catechol/heparin shielding system and immunosuppressive drug, FK506 on the survival of intraportally allotransplanted islets
Keywords: Pancreatic islets; Double-layer shielding; 8-arm-PEG; Heparin; FK506; Islet transplantation;
FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells
Keywords: Cyps; cyclophilins; FKBPs; immunophilin; FKBP52; FK506 binding protein (52); ER; rough endoplasmic reticulum; SERCA2b; sarco-endoplasmic Ca2Â +-ATPase isotype 2b; IP3R II; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potential channel;
AT motif binding factor 1 (ATBF1) is highly phosphorylated in embryonic brain and protected from cleavage by calpain-1
Keywords: ATBF1; ZFHX3; Phosphorylation; Calpain-1; Protein stability; FK506
Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506
Keywords: EC50; 50% effective inhibitory concentration; RLU; relative light units; SARS-CoV; HCoV-NL63; HCoV-229E; FK506; Tacrolimus; Immunophilins; FKBP1A (FKBP12); FKBP1B (FKBP12.6); Inhibition of viral replication;
Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation
Keywords: Osteoclast; ITAM; Calcineurin; NFATc1; FK506; VIVIT; β3 Integrin; Annexin VIII
Microarray gene expression profiling of chronic allograft nephropathy in the rat kidney transplant model
Keywords: Chronic allograft nephropathy; Kidney transplantation; Immunosuppression; FK506; Microarray; Gene expression profiling
Involvement of intestinal intraepithelial lymphocytes in turnover of intestinal epithelial cells: Morphological and functional alterations due to daily administration of FK506
Keywords: Intestinal intraepithelial lymphocytes (IELs); Intestinal epithelial cells (IECs); FK506; Turnover; Alkaline phosphatase; CD98; Microvilli;
Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain
Keywords: Tacrolimus; FK506; Dendritic spine; Dendrite branching; Sholl plot; Survival analysis;
Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice
Keywords: Alzheimer; Dendritic spine; FK506; Tacrolimus; Synapse; Transgenic
Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury
Keywords: CVD, cardiovascular disease; CT-1, cardiotrophin-1; HSP, heat shock protein; I/R, ischaemia/reperfusion; NRCM, neonatal rat cardiac myocytesCardiotrophin-1; Heat shock protein; HSP56; FK506; FKBP52; Hypertrophy; Ischaemia/reperfusion (I/R) injury; Transge
FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1
Keywords: Multiple resistance drugs; FK506; Mrp1; Glioblastoma multiforme;
Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production
Keywords: AP-1; activating protein-1; CaN; calcineurin; CsA; Cyclosporine A; CyP; cyclophilin; ERK; extracellular signal-regulated protein kinase; FCS; fetal calf serum; FK506; Tacrolimus; IP3; inositol triphosphate; JNK; c-Jun NH2-terminal kinases; MAPK; mitogen-a
Myeloablative Irradiation, Granulocyte-Colony Stimulating Factor, and FK506 can Induce Macrochimerism and Prolong the Survival of Experimental Extremity Allografts
Keywords: limb allograft; chimerism; tolerance; total body irradiation; granulocyte colony-stimulation factor; FK506
Allograft Inflammatory Factor-1 is Up-regulated in Warm and Cold Ischemia-Reperfusion Injury in Rat Liver and May be Inhibited by FK506
Keywords: allograft inflammatory factor-1; ischemia-reperfusion injury; FK506; liver transplantation
FK506 ameliorates renal injury in early experimental diabetic rats induced by streptozotocin
Keywords: Diabetic nephropathy; FK506; Calcineurin; α-Smooth muscle actin; Transforming growth factor-β1;
Discovery of a novel neuroprotective compound, AS1219164, by high-throughput chemical screening of a newly identified apoptotic gene marker
Keywords: AS1219164; FK506; Diclofenac; Neuroprotection; TMEM100 gene; LBH gene;
Diverse Effects of FK506 on the Apoptosis of Hepatocytes and Infiltrating Lymphocytes in an Allografted Rat Liver
Keywords: FK506; apoptosis; liver transplantation; Fas; Fas ligand; Bax; Bcl-2
Brazilian green propolis and its constituent, Artepillin C inhibits allogeneic activated human CD4 T cells expansion and activation
Keywords: Allo-HSCT; allogeneic hematopoietic stem cell transplantation; APC; antigen presenting cells; Art-C; Artepillin C; CFSE; carboxyfluorescein succinimidyl ester; CsA; cyclosporine A; Foxp3; forkhead box p3; FK506; tacrolimus; GVHD; graft versus host disease
FK506 ameliorates cell death features in Huntington's disease striatal cell models
Keywords: 3-Nitropropionic acid; Cell death; FK506; Mutant huntingtin; Mitochondrial dysfunction; Striatal neurons;
Surface camouflage of pancreatic islets using 6-arm-PEG-catechol in combined therapy with tacrolimus and anti-CD154 monoclonal antibody for xenotransplantation
Keywords: Pancreatic islets; Surface camouflage; 6-arm-PEG-catechol; Anti-CD154 mAb; FK506
Immunosuppressant cytoprotection correlates with HMGB1 suppression in primary astrocyte cultures exposed to combined oxygen-glucose deprivation
Keywords: HMGB1; cyclosporine A; FK506; rapamycin; astrocytes; ischemia; iNOS; COX-2