FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1

► FK506 a chemosensitizer for human glioblastoma multiforme cells. ► FK506 decrease expression of the multiple drug resistance transporter Mrp1. ► Potential use of FK506 for clinical trials of human glioblastoma.