کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2597534 1562410 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity
چکیده انگلیسی

Cis-diamminedichloroplatinum (II) (cisplatin) is an effective chemotherapeutic agent successfully used in the treatment of a wide range of tumors; however, nephrotoxicity has restricted its clinical use. Several studies have shown that reactive oxygen species are involved in cisplatin-induced nephrotoxicity, including hydrogen peroxide, hydroxyl radical and superoxide anion (O2−). The source of O2− in cisplatin-induced renal damage has not been established. The aim of this study was to investigate if NADPH oxidase is involved in cisplatin-induced nephrotoxicity using apocynin, a widely used NADPH oxidase inhibitor. Rats were studied 3 days after a single injection of cisplatin (7.5 mg/kg, i.p.). Apocynin was given in the drinking water (2 g/L) 7 days before and 3 days after cisplatin injection. Apocynin treatment was able to ameliorate the renal histological damage and the increase in blood urea nitrogen, serum creatinine, and urinary excretion of total protein, N-acetyl-β-d-glucosaminidase and glutathione-S-transferase induced by cisplatin. In addition, the protective effect of apocynin was associated with the amelioration of cisplatin-induced oxidative and nitrosative stress. Our data suggest that O2− derived from NADPH oxidase triggers some of the side effects due to cisplatin administration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 245, Issues 1–2, 12 March 2008, Pages 18–23
نویسندگان
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