کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2597728 1562421 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products
چکیده انگلیسی

Curcumin (diferuloylmethane) is a major yellow pigment and dietary component derived from Curcuma longa. It has potent anti-inflammatory, anticarcinogenic, antioxidant and chemoprotective activities among others. We studied the interactions of curcumin, a mixture of its decomposition products, and four of its individually identified decomposition products (vanillin, vanillic acid, ferulic aldehyde and ferulic acid) on five major human drug-metabolizing cytochrome P450s (CYPs). Curcumin inhibited CYP1A2 (IC50, 40.0 μM), CYP3A4 (IC50, 16.3 μM), CYP2D6 (IC50, 50.3 μM), CYP2C9 (IC50, 4.3 μM) and CYP2B6 (IC50, 24.5 μM). Curcumin showed a competitive type of inhibition towards CYP1A2, CYP3A4 and CYP2B6, whereas a non-competitive type of inhibition was observed with respect to CYP2D6 and CYP2C9. The inhibitory activity towards CYP3A4, shown by curcumin may have implications for drug–drug interactions in the intestines, in case of high exposure of the intestines to curcumin upon oral administration. In spite of the significant inhibitory activities shown towards the major CYPs in vitro, it remains to be established, whether curcumin will cause significant drug–drug interactions in the liver, given the reported low systemic exposure of the liver to curcumin. The decomposition products of curcumin showed no significant inhibitory activities towards the CYPs investigated, and therefore, are not likely to cause drug–drug interactions at the level of CYPs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 235, Issues 1–2, 3 June 2007, Pages 83–91
نویسندگان
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