کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2598171 | 1562435 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mechanism of DNA damage induced by bromate differs from general types of oxidative stress Mechanism of DNA damage induced by bromate differs from general types of oxidative stress](/preview/png/2598171.png)
A representative reactive oxygen species (ROS), hydroxyl radical (OH), is a highly reactive species and induces DNA backbone breakage. OH also oxidizes every DNA base. The interaction of OH with guanine leads to the generation of not only piperidine-resistant 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) but also various piperidine-labile products. On the other hand, potassium bromate (KBrO3) induces specific formation of 8-oxodG in the presence of SH compounds, such as glutathione (GSH) and cysteine (Cys). GSH/Cys reduces KBrO3 (BrO3−) to BrO2, which abstracts one electron from guanine. The one-electron oxidation of guanine may yield cation radicals followed by the reaction with a water molecule, leading to 8-oxodG formation. Therefore, mechanism of bromate-induced oxidative DNA damage is different from general types of oxidative stress such as OH.
Journal: Toxicology - Volume 221, Issues 2–3, 17 April 2006, Pages 172–178