کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2598357 1562617 2016 14 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of neuroendocrine cells and neuron factors in the ovary by zinc oxide nanoparticles
ترجمه فارسی عنوان
تنظیم سلول های اعصاب و غدد و عوامل نرون در تخمدان با استفاده از نانوذرات اکسید روی
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کلمات کلیدی
نانوذرات اکسید روی؛ بلوغ؛ تخمدان؛ عوامل نورون؛ سلول های اعصاب و غدد
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• First in vivo investigation of the effects of ZnO NPs on neuron factors and neuroendocrine cells.
• ZnO NP altered gene and protein expression of neuron factors in ovary.
• ZnO NPs treatments differentially regulated the population of neuroendocrine cellsin ovary.
• ZnO NPs also changed the essential elements contents in ovary.
• ZnO NPs might adversely affect neuron systems in ovary.

The pubertal period is an important window during the development of the female reproductive system. Development of the pubertal ovary, which supplies the oocytes intended for fertilization, requires growth factors, hormones, and neuronal factors. It has been reported that zinc oxide nanoparticles (ZnO NPs) cause cytotoxicity of neuron cells. However, there have been no reports of the effects of ZnO NPs on neuronal factors and neuroendocrine cells in the ovary (in vivo). For the first time, this in vivo study investigated the effects of ZnO NPs on gene and protein expression of neuronal factors and the population of neuroendocrine cells in ovaries. Intact NPs were detected in ovarian tissue and although ZnO NPs did not alter body weight, they reduced the ovary organ index. Compared to the control or ZnSO4 treatments, ZnO NPs treatments differentially regulated neuronal factor protein and gene expression, and the population of neuroendocrine cells. ZnO NPs changed the contents of essential elements in the ovary; however, they did not alter levels of the steroid hormones estrogen and progesterone. These data together suggest that intact ZnO NPs might pose a toxic effect on neuron development in the ovary and eventually negatively affect ovarian developmental at puberty.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 256, 10 August 2016, Pages 19–32
نویسندگان
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