کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2598358 1562617 2016 11 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
ترجمه فارسی عنوان
تفاوت های فشار سمیت ناشی از کادمیوم در رتها: بینش از پاسخ های ایمنی طحال و ریه
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کلمات کلیدی
کادمیوم؛ موش صحرائی؛ نژاد آلبینو آکسفورد (AO) و تیره آگوتی (DA) سویه؛ طحال؛ شش
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Strain differences in acute cadmium immunotoxicity are explored in DA and AO rats.
• Cadmium affected spleen and lungs cells immune response in DA and AO rats.
• The degree of some changes differ between strains in both compartments.
• Data depict complex influence of genetic background on the cadmium immunotoxicity.

The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell’s proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-γ)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b+ cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-γ responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 256, 10 August 2016, Pages 33–43
نویسندگان
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