کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2636808 1563479 2014 8 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Application of quantitative microbial risk assessment for selection of microbial reduction targets for hard surface disinfectants
ترجمه فارسی عنوان
استفاده از ارزیابی کمی خطر میکروبی برای انتخاب اهداف کاهش میکروبی برای ضدعفونی کننده های سطح سخت
کلمات کلیدی
آلودگی سطح میکروبی؛ Fomite؛ پاسخ ـ دز
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
چکیده انگلیسی

BackgroundThis quantitative microbial risk assessment (QMRA) included problem formulation for fomites and hazard identification for 7 microorganisms, including pathogenic Escherichia coli and E coli 0157:H7, Listeria monocytogenes, norovirus, Pseudomonas spp, Salmonella spp, and Staphylococcus aureus. The goal was to address a risk-based process for choosing the log10 reduction recommendations, in contrast to the current US Environmental Protection Agency requirements.MethodFor each microbe evaluated, the QMRA model included specific dose-response models, occurrence determination of aerobic bacteria and specific organisms on fomites, exposure assessment, risk characterization, and risk reduction. Risk estimates were determined for a simple scenario using a single touch of a contaminated surface and self-inoculation. A comparative analysis of log10 reductions, as suggested by the US Environmental Protection Agency, and the risks based on this QMRA approach was also undertaken.ResultsThe literature review and meta-analysis showed that aerobic bacteria were the most commonly studied on fomites, averaging 100 colony-forming units (CFU)/cm2. Pseudomonas aeruginosa was found at a level of 3.3 × 10−1 CFU/cm2; methicillin-resistant S aureus (MRSA), at 6.4 × 10−1 CFU/cm2. Risk estimates per contact event ranged from a high of 10−3 for norovirus to a low of 10−9 for S aureus.ConclusionThis QMRA analysis suggests that a reduction in bacterial numbers on a fomite by 99% (2 logs) most often will reduce the risk of infection from a single contact to less than 1 in 1 million.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Infection Control - Volume 42, Issue 11, November 2014, Pages 1165–1172
نویسندگان
, , , , , ,