کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2639313 1563488 2014 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
The role of tissue plasminogen activator use and systemic hypercoagulability in central line-associated bloodstream infections
ترجمه فارسی عنوان
نقش استفاده از فعال کننده بافتی پلاسمینوژن و انعقاد سیستمیک در عفونت های جریان خون مرتبط با خط مرکزی
کلمات کلیدی
ترومبوز عروقی؛ عفونت مرتبط با مراقبت های بهداشتی؛ عفونت دستگاه پزشکی؛ اپیدمیولوژی مراقبت های بهداشتی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
چکیده انگلیسی

BackgroundCentral line-associated bloodstream infections (CLABSIs) impact patient outcomes and increase cost of hospitalization. In situ thrombus is known to promote microbial adhesion and colonization and potentially lead to CLABSI. Clinical validation of this theory, adjusting for presence of systemic hypercoagulability, is needed.MethodsThis study is a retrospective review of all adult and pediatric patients with peripherally inserted central catheter placement over a 4-year period at our tertiary care center. Tissue plasminogen activator (TPA) use was utilized as indicator for line site thrombus. CLABSIs rates were compared in patients with or without TPA use, adjusting for the presence of hypercoagulable conditions, age, and severity of illness.ResultsA total of 3,723 patients with peripherally inserted central catheter lines was evaluated, 40% of whom received TPA. The adjusted odds of developing a CLABSI was 3.59 times greater in those patients who received TPA compared with those who did not (95% confidence interval [CI]: 1.86-6.94). Neither severity of illness (odds ratio [OR], 1.00; 95% CI: 0.51-1.96) nor primary (OR, 3.41; 95% CI: 0.43-26.7) or secondary hypercoagulability (OR, 0.91; 95% CI: 0.44-1.88) were statistically associated with a higher risk of infection.ConclusionThe use of TPA, as a possible indicator in situ thrombus, was associated with a higher risk of developing CLABSI. Neither primary nor secondary hypercoagulability was correlated with risk of developing CLABSI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Infection Control - Volume 42, Issue 4, April 2014, Pages 417–420
نویسندگان
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