کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2639366 | 1563562 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Investigation of an outbreak of Serratia marcescens in a neonatal unit via a case-control study and molecular typing Investigation of an outbreak of Serratia marcescens in a neonatal unit via a case-control study and molecular typing](/preview/png/2639366.png)
BackgroundIn March 2004, infection or colonization with Serratia marcescens affected one third of all neonates in a newborn services unit (NBS).MethodsWe performed a case-control study and automated ribotyping.ResultsForty-nine cases were compared with 64 controls. The overall mean length of stay (LOS) in the NBS was 67 days for cases and 36 days for controls, P = .005. Cases were of lower mean birth weight than controls (1566 g vs 1968 g, respectively, P = .02). Risk factors that trended toward significance for S marcescens acquisition included the following: premature rupture of membranes (odds ratio [OR], 2.7; 95% confidence interval [95% CI]: 1.0-7.1; P = .05), vaginal delivery at our hospital (OR, 2.1; 95% CI: 0.9-4.6; P = .06), intubation at delivery (OR, 2.3; 95% CI: 0.9-5.2; P = .05), mechanical ventilation (OR, 2.1; 95% CI: 0.9-4.4; P = .06), and theophylline treatment (OR, 2.5; 95% CI: 1.1-5.4; P = .02). Multiple logistic regression analysis revealed vaginal delivery at our hospital (OR, 3.4; 95% CI: 1.4-8.2; P = .007) and LOS >30 days (OR, 4.4; 95% CI: 1.8-10.6; P = .001) as independent risk factors for S marcescens acquisition. Ribotyping of specimens revealed 5 restriction patterns.ConclusionCases were of lower birth weight than controls, were born by vaginal delivery at our hospital, had longer LOS in NBS, and had greater requirements for respiratory support. Ribotyping of specimens revealed that this outbreak was not clonal.
Journal: American Journal of Infection Control - Volume 36, Issue 1, February 2008, Pages 22–28