Appropriate Use of Naloxone in the Clinical Setting

Naloxone is an opioid antagonist that competitively binds to opioid receptors and reverses all of their effects. The indication for use is respiratory depression as a result of known or suspected opioid overdose. Clinicians involved in patient care must use the drug appropriately, rather than as a diagnostic tool, such as to determine the etiology of a change in mental status. This article reviews the pharmacokinetics and pharmacodynamics of naloxone. In addition, the appropriate administration is reviewed using a case study approach.