کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2668774 1141028 2014 6 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Changes in epidermal thickness and cutaneous innervation during maturation in long-term diabetes
ترجمه فارسی عنوان
تغییرات در ضخامت اپیدرمی و ناهنجاری پوستی در طول بلوغ در دیابت بلندمدت
کلمات کلیدی
دیابت قندی، موش صحرایی؛ پوست؛ مغز و اعصاب؛ بلوغ
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی

AimPeripheral nerve fiber depletion in patients with chronic diabetes mellitus (DM) was linked to neuropathic symptoms, development of pain, foot ulcerations and lower extremity amputation. The aim of this study was to analyze cutaneous changes, including paw epidermal thickness and intraepidermal nerve fiber (IENF) density in long-term diabetes, in rats 6 months and 12 months after induction of diabetes.Materials and methodsEpidermal thickness and IENF density were studied in Sprague–Dawley diabetic rats 6 months and 12 months after diabetes induction with streptozotocin. Epidermal thickness was evaluated using hematoxylin and eosin staining. Peripheral nerve fibers were stained with polyclonal antiserum against protein gene product 9.5 (PGP 9.5). Successful diabetes induction was validated by measuring plasma glucose and body mass regularly throughout the experiment.ResultsThis study showed that long-term diabetes, induced in Sprague–Dawley rats with streptozotocin, is characterized with significant epidermal thinning and reduction of intraepidermal nerve fibers, 6 months and 12 months after induction of diabetes.ConclusionLong-term studies of streptozotocin models of diabetes could be used for making normative IENF densities that can be later used as age-dependent normative values for studying new treatment modalities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Tissue Viability - Volume 23, Issue 1, February 2014, Pages 7–12
نویسندگان
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