کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2683690 | 1142680 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effet obésogène du bisphénol A sur des souris C57Bl/6 sous régime hyperlipidique
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
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![عکس صفحه اول مقاله: Effet obésogène du bisphénol A sur des souris C57Bl/6 sous régime hyperlipidique Effet obésogène du bisphénol A sur des souris C57Bl/6 sous régime hyperlipidique](/preview/png/2683690.png)
چکیده انگلیسی
Human exposure to BPA is low but it occurs during the lifetime and gestation appears to be a critical exposure windows. BPA is an endocrine disruptor which could induce alteration in energy metabolism and obesity development. Pregnant mice were exposed to BPA (0.2, 20 and 2000 μg/kg bw per day) and offsprings were fed with a high fat diet (HFD). Energy expenditure, fat mass and lean masses were measured. A lipid load test was performed in order to determine a potential disturbance of intestine lipid metabolism. BPA induced a effect gender- and dose-dependent effect (non monotonic effect). Only BPA-exposed male offspring exhibited a higher overweight (in correlation with fat mass) than control. A decrease of energy expenditure, a post-prandial hypotriglyceridemia and liver steatosis were observed. BPA appears to potentiate HFD-induced obesity and to alter lipid metabolism in adipose tissue, liver and intestine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cahiers de Nutrition et de Diététique - Volume 48, Issue 3, June 2013, Pages 129-136
Journal: Cahiers de Nutrition et de Diététique - Volume 48, Issue 3, June 2013, Pages 129-136
نویسندگان
Ludovic Le Corre, Lydie Ivry-Del Moral, Philippe Besnard, Marie-Christine Chagnon,