کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2687603 1143029 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of short-term oral administration of dietary marine oils in patients with inflammatory bowel disease and joint pain: A pilot study comparing seal oil and cod liver oil
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Effects of short-term oral administration of dietary marine oils in patients with inflammatory bowel disease and joint pain: A pilot study comparing seal oil and cod liver oil
چکیده انگلیسی

SummaryBackgroundVery long chain n-3 polyunsaturated fatty acids have modulating effects on inflammatory mechanisms. Seal and fish oils are rich in n-3 polyunsaturated fatty acids, and possibly therefore high doses of nasoduodenally administered seal oil rapidly relieved inflammatory bowel disease (IBD)-associated joint pain in two recent studies. In the present study, we compared the effects of short-term oral administration of seal oil and cod liver oil on IBD-related joint pain, leucotriene B4 level, serum fatty acid profile and IBD activity.MethodsThirty-eight patients with IBD-related joint pain were included in the study; 21 had Crohn's disease and 17 ulcerative colitis. Ten milliters of seal oil (n = 18) or cod liver oil (n = 20) was self-administered orally 3 times a day for 14 days before meals in a double-blind setting.ResultsThere were no significant differences between the two intervention groups or between Crohn's disease and ulcerative colitis patients. There was a tendency toward improvement in several joint pain parameters after both seal oil and cod liver oil administration. Further, plasma leucotriene B4 concentration, serum Σ n-6 to Σ n-3, and arachidonic acid (20:4n-6) to eicosapentaenoic acid (20:5n-3) ratios were similarly reduced after administration of seal oil and cod liver oil.ConclusionNo significant differences in the two treatment groups were seen; in both groups, the changes in several joint pain parameters, leucotriene B4 level of plasma, and serum fatty acid profile were putatively favourable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 27, Issue 4, August 2008, Pages 614–622
نویسندگان
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