کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2687827 | 1143049 | 2014 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei](/preview/png/2687827.png)
Extract rich in glucans from the Caripia montagnei mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and parecoxib. Agonists of PPARα showed a value of 90.8 ± 10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9 ± 7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in leukocyte migration, in addition to modest nitric oxide production. The polymer antiangiogenic activity showed a high inhibiting concentration of 1000 μg/egg. This study also investigated total antioxidant activity (57 ± 0.3%), reducing power (37.6 ± 0.16), and lipid peroxidation (84 ± 0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0 ± 0.01% (1 mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from Caripia montagnei has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.
Journal: Biomedicine & Preventive Nutrition - Volume 4, Issue 2, April–June 2014, Pages 121–129