کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2689068 1564702 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combined action of Silymarin and Celecoxib in modulating inflammatory mediators in osteoarthritis
ترجمه فارسی عنوان
عمل ترکیبی سیلیمارین و سلکوکسیب در تعدیل واسطه های التهابی در استئوآرتریت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

Inflammation is the hallmark of osteoarthritis (OA) leading to pain and disability. Objective of this investigation was to evaluate the effect of Silymarin (SMN, an antioxidant), Celecoxib (CLX, a selective COX inhibitor) and their combination on chemically induced arthritis in rats. The biochemical parameters and radiology impact of the treatment was also determined. Wistar male rats were assigned into five groups including control, OA+, OA+ CLX (100 mg/kg), OA+ SMN (50 mg/kg) and OA+ CLX + SMN (25 mg/kg). Combined treatment returned the elevated levels of inflammatory mediators (ROS, TNF-α, ALP, COX-2) to normal levels in 14 days. In the SMN + CLX treated animals significant reduction in KL grade and normal joint space narrowing was observed. X-ray radiological studies supported the biochemical findings. These findings suggest that co-administration of SMN with CLX could be an effective antiarthritic treatment which can equally abolish the arthritis associated secondary complication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Preventive Nutrition - Volume 4, Issue 4, October–December 2014, Pages 485–490
نویسندگان
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