Risque thromboembolique et bevacizumab : données de la littérature et recommandations pour l'utilisation des anticoagulants et antiagrégants

Bevacizumab is a monoclonal antibody against vascular endothelial growth factor. The use of bevacizumab has shown survival benefit in variety of cancers. However, a specific toxicity profile has been observed with bevacizumab such as hypertension, proteinuria, gastrointestinal perforation and arterial thrombosis. Non-small-cell lung cancer is often associated with thrombotic event therefore guidelines are expected to prescribe bevacizumab in this population. This article presents data from litterature about the thrombotic risk and provides recommendations for the use of anticoagulant and antiagrégant treatements.