کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2709912 | 1144984 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quelles options pour la chimiothérapie de première ligne des CBNPC de stade IV ?
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کلمات کلیدی
Histology - بافت شناسیhistologie - بافت شناسیTargeted therapies - درمان های هدفمندSujets âgés - سالمندانFirst-line chemotherapy - شیمی درمانی اولMaintenance - عملیات نگهداری و تعمیراتCarcinome bronchique non à petites cellules - کارسینوم ریه سلول غیر سلولیNon-small cell carcinoma - کارسینوم سلول غیر سلولی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Until recently, first-line chemotherapy for advanced non-small cell lung cancer (NSCLC) was based on ASCO guidelines. Since several years, first-line chemotherapy is a platin-based doublet for patients with a good performans status. For elderly or unfit patients, a single-drug chemotherapy or a combination without cisplatin was recommended. The association of an anti-angiogenic therapy, bevacizumab, with carboplatin-paclitaxel or cisplatin-gemcitabine regimens improves progression-free survival for patients with non-epidermoid tumors. The combination of cisplatin and pemetrexed is better in terms of survival than cisplatine-gemcitabine in these tumors. The choice of treatment according to histology is becoming a new concept. Another is maintenance therapy. The main objective is to reduce duration of platin-based chemotherapy while improving quality of life and progression-free survival. This concept is ongoing validation. The combination of cetuximab with platin-chemotherapy improves survival for all histologic types. We should integrate this new approach among other available treatments. First-line therapy for advanced NSCLC is changing. In the future, first-line therapy will be chosen according to clinical features and biomarkers such as gene mutations of EGFR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue des Maladies Respiratoires - Volume 26, Issue 10, December 2009, Pages 1091-1096
Journal: Revue des Maladies Respiratoires - Volume 26, Issue 10, December 2009, Pages 1091-1096
نویسندگان
P. Fournel,