کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2717684 1566277 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pulmonary Adverse Events of Anti-Tumor Necrosis Factor-α Antibody Therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Pulmonary Adverse Events of Anti-Tumor Necrosis Factor-α Antibody Therapy
چکیده انگلیسی
It is well established that anti-tumor necrosis factor-α (TNFα) antibody is an efficacious disease-modifying drug for rheumatoid arthritis and Crohn's disease. Unfortunately, its long-term use can be associated with ominous pulmonary adverse events, most notably mycobacterial and fungal lung infections. To this end, reactivation of latent tuberculosis infection represents a serious concern of anti-TNFα antibody therapy. Given the anticipated increase in the approved indications for these drugs, community-based physicians should be made aware of these events for implementation of better patient selection for anti-TNFα antibody therapy and initiation of appropriate measures once these adverse events are observed. This review will address this issue by outlining: 1) the role of TNFα in host inflammatory response to injury, particularly during mycobacterial and fungal infections; 2) the salutary effects of anti-TNFα antibody therapy in human diseases; and 3) the ominous pulmonary adverse events associated with these drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Medicine - Volume 119, Issue 8, August 2006, Pages 639-646
نویسندگان
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