Impact of NSAIDS on Mortality and the Effect of Preexisting Coronary Artery Disease in US Veterans

As in previous reports, there was an increased risk of cardiovascular and cerebrovascular events for NSAIDs. However, NSAID exposure was associated with a reduced risk of death. This study raises important questions about NSAIDs in patients with osteoarthritis given that they seem to increase the risk of cardiovascular events but decrease overall mortality.