کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2722631 1566675 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Update on prostate cancer in black men
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Update on prostate cancer in black men
چکیده انگلیسی

BackgroundCarcinoma of the prostate (CaP) is the most common male malignancy worldwide and the highest incidence has been recorded in black men. CaP appears to have a more aggressive biology in this sub-population but the reasons for these observed differences have not been fully elucidated. This article is a review of the current published evidence on the disease in black men.MethodsWe searched Pubmed and Google for articles on CaP with an emphasis on those focusing on sub-population differences. Published abstracts of presentations at international scientific meetings were also reviewed.ResultsMolecular studies suggest that black men have a genetic predisposition to the development and/or progression of CaP. Variations in several genes and cellular pathways have been implicated in their increased CaP risk. Clinicopathologic differences include more prevalent and extensive high grade prostatic intraepithelial neoplasia (HGPIN) and higher prostate-specific antigen (PSA) values at initial diagnosis. Sociocultural differences in access and uptake of health care resulting in delayed presentation along with differential care are also thought to contribute to the poorer outcomes associated with prostatic malignancy in black men.ConclusionConsiderable evidence exists on the effect of black ethnicity on the molecular and clinical characteristics of CaP. More studies into the racial differences in the incidence and prognosis of CaP are required to provide information about the mechanisms responsible for this observation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Men's Health & Gender - Volume 4, Issue 4, December 2007, Pages 456–463
نویسندگان
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