کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2728478 1146990 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteomic analysis of the plasma samples of patients with stable angina pectoris
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Proteomic analysis of the plasma samples of patients with stable angina pectoris
چکیده انگلیسی

ObjectiveIn this study, the results of the proteomic analysis of plasma samples of stable angina patients are presented.BackgroundPlasma samples from 44 patients were analysed in two groups: (A) a control group of 22 patients without significant coronary artery disease and (B) 22 patients admitted with stable angina pectoris.MethodsDuring coronary angiography, plasma samples were collected and further analysed using two-dimensional gel electrophoresis, image analysis and mass spectrometry.ResultsFive spots were found with significantly increased or decreased normalised volumes resulting from either a change in the amount of protein or changes in posttranslational modifications. Spots containing serum amyloid A protein and fibrinogen gamma chains displayed increased normalised volumes, and spots containing apoliprotein A-1 and pigment epithelium derived factor showed decreased normalised volumes.ConclusionsAlmost identical proteomic profiles of the stable angina pectoris group compared with the control group corresponded well with clinical results comparing stable patients with the general population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cor et Vasa - Volume 54, Issue 1, January–February 2012, Pages e22–e26
نویسندگان
, , , , , , , , ,