Anwendungsoptionen und Evidenz für PRP (platelet-rich plasma) in der Orthopädie

SummaryThe use of orthobiologics and the progress in tissue engineering have an important and increasing impact in orthopedic surgery. Especially the use of PRP (platelet-rich plasma) is one of the most intense investigated therapeutical options in this field. The application of an autologue, platelet enriched suspension is supposed to cause multiple effects: The induction of a local inflammation process and the release and activation of multiple growth factors within complex signaling cascades. This is included in the wound healing process supporting tissue regeneration. The use and especially a detailed review of the evidence for PRP remains difficult. A clear definition of the cellular composition of PRP in the literature is still missing. Additionally the options to apply PRP are heterogeneous and complicate a final assessment. In the literature a supporting beneficial effect of PRP is described for rotator cuff repair and treatment of tennis-elbow, as well as wound- and bone healing. In Summary PRP is a promising and interesting tool for orthopedic surgeons to support established treatment algorithms. Large prospective, randomized-controlled trials are essential to assess and decide about the use of PRP in the future.