کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2750507 1149340 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of the Apparent Diffusion Coefficient in the Prediction of Response to Neoadjuvant Chemotherapy in Patients With Locally Advanced Breast Cancer
ترجمه فارسی عنوان
نقش ضریب اشباع آشکار در پیش بینی پاسخ به شیمیدرمانی نوآویوانانت در بیماران مبتلا به سرطان پستان پیشرفته محلی
کلمات کلیدی
فنوتیپ های سرطان پستان، تصویربرداری با وزن زیاد تصویربرداری رزونانس مغناطیسی، پیش بینی پاسخ
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

BackgroundWe evaluated the diagnostic performance of the baseline diffusion weighted imaging (DWI) and the apparent diffusion coefficient (ADC) in the prediction of a complete pathologic response (pCR) to neoadjuvant chemotherapy (NAC) in patients with breast cancer stratified according to the tumor phenotype.Patients and MethodsWe retrospectively studied 225 patients with stage II, III, and IV breast cancer who had undergone contrast-enhanced magnetic resonance imaging (MRI) and DWI before and after NAC, followed by breast surgery.ResultsThe tumor phenotypes were luminal (n = 143; 63.6%), triple-negative (TN) (n = 37; 16.4%), human epidermal growth factor receptor 2 (HER2)-enriched (n = 17; 7.6%), and hybrid (hormone receptor-positive/HER2+; n = 28; 12.4%). After NAC, a pCR was observed in 39 patients (17.3%). No statistically significant difference was observed in the mean ADC value between a pCR and no pCR in the general population (1.132 ± 0.191 × 10−3 mm2/s vs. 1.092 ± 0.189 × 10−3 mm2/s, respectively; P = .23). The optimal ADC cutoff value in the general population was 0.975 × 10−3 mm2/s (receiver operating characteristic [ROC] area under the curve [AUC], 0.587 for the prediction of a pCR). After splitting the population into subgroups according to tumor phenotype, we observed a significant or nearly significant difference in the mean ADC value among the responders versus the nonresponders in the TN (P = .06) and HER2+ subgroups (P = .05). No meaningful difference was seen in the luminal and hybrid subgroups (P = .59 and P = .53, respectively). In contrast, in the TN and HER2+ subgroups (cutoff value, 0.995 × 10−3 mm2/s and 0.971 × 10−3 mm2/s, respectively), we observed adequate ROC AUCs (0.766 and 0.813, respectively).ConclusionThe pretreatment ADC value is not capable of predicting the pCR in the overall population of patients with locally advanced breast cancer. Nonetheless, an ameliorated diagnostic performance was observed in specific phenotype subgroups (ie, TN and HER2+ tumors).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Breast Cancer - Volume 15, Issue 5, October 2015, Pages 370–380
نویسندگان
, , , , , , , , , , ,