کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2752654 1149577 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Therapeutic Considerations in Patients with Metastatic Renal Cell Carcinoma Previously Treated with Antiangiogenic Therapies
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Therapeutic Considerations in Patients with Metastatic Renal Cell Carcinoma Previously Treated with Antiangiogenic Therapies
چکیده انگلیسی

The recent application of antiangiogenic therapies has opened a new corridor of treatment in metastatic renal cell carcinoma. These therapies influence intracellular pathways that are important in angiogenesis and tumor progression. Although each of these agents produces objective responses as well as progression-free survival benefits, durable complete responses have not generally been observed, and thus, resistance to these chronic therapies is almost universal. The increasing use and eventual resistance to these agents has defined an increasing population of patients with targeted therapy–refractory disease. However, there are limited clinical and preclinical data to guide treatment decisions for these patients. This review will examine the existing data in this setting, describe ongoing clinical investigations, and discuss challenges unique to this patient population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Genitourinary Cancer - Volume 5, Supplement 1, December 2006, Pages S40-S44