Human Immunodeficiency Virus–Associated Lung Carcinoma Presenting as Cutaneous Metastases

In the era of highly active antiretroviral therapy (HAART), HIV-positive individuals are increasingly presenting with Non–AIDS-defining cancers such as lung carcinoma. These neoplasms tend to exhibit aggressive clinical behavior and often present with metastatic disease. We present 2 cases of lung carcinoma that manifested initially with cutaneous metastases. Both patients were men (37 and 43 years old) with known AIDS that presented with multiple skin nodules mainly on the trunk (back and shoulder). These cases demonstrate that cutaneous metastases might represent the first sign of an internal HIV-related malignancy. Recognition of skin metastases is important for prompt diagnosis and initiation of proper therapy. With the growing problem of Non–AIDS-defining cancers in the current era of HAART, clinicians should be aware that skin lesions in the HIV-infected individual might represent metastatic disease.