کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2754940 1149800 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Patterns of Central Nervous System Involvement in Relapsed and Refractory Multiple Myeloma
ترجمه فارسی عنوان
الگوهای مشارکت سیستم عصبی مرکزی در مبتلایان به میلومای چندگانه عودکننده و مقاوم
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

BackgroundInvasion of CNS in MM is an extremely rare occurrence that is associated with advanced disease with poor prognosis.Patients and MethodsOur MM database identified 35 CNS MM cases presenting between January 1996 and March 2012. Descriptive analyses were performed on available data on patient characteristics, disease course, and outcomes.ResultsThe mean age at diagnosis was 55.4 years; 23.5% (n = 8) patients had elevated levels of beta-2-microglobulin > 5.5 mg/L; 68.6% (n = 24) of patients had elevated lactate dehydrogenase (LDH) levels (≥ 2 times upper limit of normal); and 14% (n = 5) of patients had secondary plasma cell leukemia. Magnetic resonance imaging (MRI), which was performed in 34 patients, showed diffuse or localized leptomeningeal disease in 20 patients (58.8%). Monoclonal malignant plasma cells were found by CSF analysis in all 35 patients. In total, 31 patients received chemotherapy, including intrathecal chemotherapy as a part of their treatment, with a median survival of 4 months after CNS MM diagnosis.DiscussionIn our experience, CNS MM is an aggressive terminal disease feature associated with high beta-2-microglobulin level, high LDH level, and secondary plasma cell leukemia. This study highlights an unmet need in this subset of patients with high-risk, relapsed or refractory MM.ConclusionAchieving adequate CSF penetration while limiting the off-target effects needs to be considered in MM-specific novel drug development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 14, Issue 3, June 2014, Pages 211–214
نویسندگان
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