کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2755685 1567370 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Feasibility of Concurrent Chemoradiation in Cervical Cancer Patients From Rural Background
ترجمه فارسی عنوان
امکان شبیه سازی شیمیایی همزمان در بیماران مبتلا به سرطان دهانه رحم از زمینه های روستایی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

BackgroundConcurrent chemoradiation causes toxicities such as enteritis, hematologic toxicities which may lead to treatment interruptions, and therefore inferior outcomes. Adequate supportive care is very important to complete the scheduled protocol. Most of our patients are from rural background with a heterogeneous social background (nutrition and social support). There is paucity of literature to evaluate the tolerance of this intense treatment in these groups of patients, and hence, this study was undertaken.MethodsIn this observational study, 30 rural women having carcinoma cervix treated with concurrent chemoradiation between January and July 2013 were reviewed retrospectively. They were assessed weekly for dyselectrolytemia, enteritis, and hematologic toxicity using Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria. Treatment gaps along with reasons were recorded and correlated.ResultsMedian age of patients was 54 years. Of the patients, 43.3% were International Federation of Gynecology and Obstetrics stage II and 46.7% stage III. Grade 3 enteritis was seen in 7 of 30 patients (23.3%). None (0%) had grade 3 or higher hematologic toxicity. Dyselectrolytemia–hyponatremia (46.66%), hypokalemia (26.66%), hypocalcemia (6.66%), and hypomagnesemia (10%) were noted. Two of thirty patients (6.66%) received the planned 5 cycles, cisplatin 40 mg/m2 weekly. There were treatment interruptions in radiation in 6 (20%) and treatment delays in chemotherapy in 10 (33.33%) patients.ConclusionConcurrent chemoradiation for patients from rural areas is associated with higher acute toxicities. Regular monitoring for enteritis and dyselectrolytemias and timely intervention can help improve compliance and decrease treatment interruptions and thereby achieve the optimum treatment outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Ovarian and Other Gynecologic Cancer - Volume 7, Issues 1–2, December 2014, Pages 29–32
نویسندگان
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