کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2759665 1150158 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Remote Ischemic Preconditioning Does Not Affect the Incidence of Acute Kidney Injury After Elective Abdominal Aortic Aneurysm Repair
ترجمه فارسی عنوان
پیشگیری از پیش تعیین شده ایسکمیک بر میزان بروز آسیب کلیه حاد پس از اصلاح آئوریزم آئورت شکمی انتخابی تاثیر نمی گذارد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

ObjectiveOpen abdominal aortic aneurysm (AAA) repair is associated with a high risk of renal injury with few known strategies demonstrating a reduction in this risk. Remote ischemic preconditioning (RIPC) has been identified as having the potential to minimize organ injury following major vascular surgery. This trial investigated the potential for RIPC to attenuate renal and myocardial injury in patients undergoing elective open AAA repair.DesignProspective, randomized double-blinded control trial.SettingTertiary referral hospital.ParticipantsSixty-two patients undergoing elective open AAA repair.InterventionRIPC was achieved via three 5-minute cycles of upper limb ischemia using a blood pressure cuff or control (sham cuff).MeasurementsPrimary outcome was the occurrence of renal injury, as measured by an increase in creatinine during the first 4 postoperative days. Secondary outcomes included urinary neutrophil-gelatinase-associated lipocalin (NGAL), occurrence of acute kidney injury (AKI), occurrence of myocardial injury as defined by troponin rise, incidence of postoperative complications, and mortality.There was no difference in postoperative creatinine levels, NGAL levels, or the occurrence of AKI between the groups at any postoperative time point. Similarly, there was no difference in the occurrence of myocardial injury or mortality. Of note, 6 patients in the RIPC group, while no patient in the control group, experienced postoperative complications that required repeat surgical laparotomy, potentially masking any renoprotective effects of RIPC.ConclusionRIPC did not reduce the risk of postoperative renal failure or myocardial injury in patients undergoing open AAA repair. The authors’ results do not support the introduction of this technique to routine clinical practice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiothoracic and Vascular Anesthesia - Volume 28, Issue 5, October 2014, Pages 1285–1292
نویسندگان
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