Enhancement of Proopiomelanocortin Gene Promoter Activity by Local Anesthetics in a Pituitary Cell Line

It was concluded that local anesthetics potentiate the effect of CRH or forskolin on proopiomelanocortin promoter activity without changing the intracellular cyclic AMP level. It might be possible that transcriptional regulation mediated by cyclic AMP is also enhanced by local anesthetics in the other cells.