کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2767504 | 1151142 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In Vitro Antagonism of Recombinant Ligand-Gated Ion-Channel Receptors by Stereospecific Enantiomers of Bupivacaine
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In Vitro Antagonism of Recombinant Ligand-Gated Ion-Channel Receptors by Stereospecific Enantiomers of Bupivacaine In Vitro Antagonism of Recombinant Ligand-Gated Ion-Channel Receptors by Stereospecific Enantiomers of Bupivacaine](/preview/png/2767504.png)
چکیده انگلیسی
Comparison of the antagonist potencies with local concentrations obtained in clinical use suggests that bupivacaine and its enantiomers are likely to produce extensive inhibition at the nicotinic acetylcholine, NMDA, and 5-HT3A receptors but a much weaker and probably not clinically relevant effect at the GABAA receptor. It is possible that direct effects at these receptors may contribute, at least in part, to the spinal and epidural anesthesia induced by these compounds. It is unlikely, however, that the difference of the toxicity in bupivacaine enantiomers is because of the stereoselectivities of bupivacaine at ligand-gated ion-channel receptors studied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regional Anesthesia and Pain Medicine - Volume 31, Issue 1, January 2006, Pages 19-25
Journal: Regional Anesthesia and Pain Medicine - Volume 31, Issue 1, January 2006, Pages 19-25
نویسندگان
Kazuyoshi M.D., Ph.D., Masahiro M.D., Ph.D., Takahiro M.D., Ph.D., Ichiro M.D., Ph.D., Takashi M.D., Ph.D.,