کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2775497 1152329 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exercise training enhances elastin, fibrillin and nitric oxide in the aorta wall of spontaneously hypertensive rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Exercise training enhances elastin, fibrillin and nitric oxide in the aorta wall of spontaneously hypertensive rats
چکیده انگلیسی

This work aimed to analyze the effect of low-intensity exercise training on ultrastructural and molecular aortic remodeling. Male Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were allocated into four groups: sedentary WKY (SED-WKY), exercised WKY (EX-WKY, 1 h/day, 5 days/week treadmill exercise training), sedentary SHR (SED-SHR), and exercised SHR (EX-SHR). EX-SHR showed blood pressure reduction of 26% in comparison to SED-SHR after 1 month of exercise (P < 0.05). At the 20th week, BP level was not different between EX-SHRs and WKYs. Circumferential wall tension (CWT) was higher by 77% in SED-SHRs than in SED-WKYs (P < 0.001). Exercise training reduced CWT by 30% in EX- vs. SED-SHR (P < 0.001). In SED-SHRs, endothelial cells showed large and numerous cytoplasmatic vacuoles, fragmented inner elastic lamina and scarce elastin and fibrillin, while exercise training ameliorated it in EX-SHR group. The highest eNOS immunodensity was observed in EX-SHR, which was 50% higher than EX-WKY (P < 0.01) and 120% higher than SED-SHR (P < 0.0001). In conclusion, present findings indicate beneficial effects of exercise training in hypertensive rats since it increased elastin, fibrillin and eNOS content in the aortic wall.

Research Highlights
► Exercise training attenuates tensile forces acting on aortic wall.
► Endothelial ultrastructure is preserved by exercise.
► Exercise training preserves elastin and fibrillin in hypertensive rats.
► Endothelial nitric oxide synthase expression is enhanced by exercise.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Molecular Pathology - Volume 89, Issue 3, December 2010, Pages 351–357
نویسندگان
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