کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2779313 1153266 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathophysiology of peri-articular bone changes in osteoarthritis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Pathophysiology of peri-articular bone changes in osteoarthritis
چکیده انگلیسی

Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression.This article is part of a Special Issue entitled “Osteoarthritis”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 51, Issue 2, August 2012, Pages 190–196
نویسندگان
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