کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2779625 | 1153277 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Age-related changes in bone density, geometry and biomechanical properties of the proximal femur: CT-based 3D hip structure analysis in normal postmenopausal women Age-related changes in bone density, geometry and biomechanical properties of the proximal femur: CT-based 3D hip structure analysis in normal postmenopausal women](/preview/png/2779625.png)
The geometry as well as bone mineral density (BMD) of the proximal femur contributes to fracture risk. How and the extent to which they change due to natural aging is not fully understood.We assessed BMD and geometry in the femoral neck and shaft separately, in 59 normal Japanese postmenopausal women aged 54–84 years, using clinical computed tomography (CT) and commercially available software, at baseline and 2-year follow-up. This system detected significant reductions over the 2-year interval in total BMD (%change/year = −0.900 ± 0.257, p < 0.0005), cortical cross-sectional area (CSA) (− 0.800 ± 0.423%/year, p < 0.05) and cortical thickness (−1.120 ± 0.453%/year, p < 0.01) in the femoral neck. In the femoral shaft, cortical BMD decreased significantly (− 0.642 ± 0.188%/year, p < 0.005). Regarding biomechanical parameters in the femoral neck, the cross-sectional moment of inertia (CSMI) and section modulus (SM) decreased (− 1.38 ± 3.65%/year, p < 0.01 and − 1.37 ± 2.96%/year, p < 0.005) and the buckling ratio (BR) increased significantly (1.48 ± 4.81%/year, p < 0.05), whereas no changes were found in the femoral shaft.The distinct patterns of age-related changes in the geometry and biomechanical properties in the femoral neck and shaft suggest that improved geometric measures are possible with the current non-invasive method using clinical CT.
Figure optionsDownload high-quality image (793 K)Download as PowerPoint slideResearch Highlights
► Longitudinal changes in hip geometry and biomechanical property by clinical CT.
► A decrease in cortical thickness/area at the neck demonstrated.
► A decrease in cortical density also found at the shaft.
► Worsening of biomechanical parameters revealed at the femoral neck, not at the shaft.
Journal: Bone - Volume 48, Issue 3, 1 March 2011, Pages 627–630