کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2779627 | 1153277 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Subchondral cysts create increased intra-osseous stress in early knee OA: A finite element analysis using simulated lesions Subchondral cysts create increased intra-osseous stress in early knee OA: A finite element analysis using simulated lesions](/preview/png/2779627.png)
Aim of studyTo investigate the role of intra-osseous lesions in advancing the pathogenesis of Osteoarthritis (OA) of the knee, using Finite Element Modeling (FEM) in conjunction with high-resolution imaging techniques.MethodsTwenty early stage OA patients (≤ Grade 2 radiographic score) were scanned with a prototype, cone-beam CT system. Scans encompassed the mid-shaft of the femur to the diaphysis of the proximal tibia. Individual bones were segmented to create 3D geometric models that were transferred to FE software for loading experiments. Patient-specific, inhomogeneous material properties were derived from the CT images and mapped directly to the FE models. Duplicate models were also created, with a 3D sphere (range 3–12 mm) introduced into a weight-bearing region of the joint, mimicking the size, location, and composition of a subchondral bone cyst (SBC). A spherical shell extending 1 mm radially around the SBC served as the sample volume for measurements of von Mises equivalent stress. Both models were vertically loaded with 750 N, or approximately 1 body weight during a single-leg stance.ResultsAll FE models exhibited a physiologically realistic weight-bearing distribution of stress, which initiated at the joint surface and extended to the cortical bone. Models that contained the SBC experienced a nearly two-fold increase in stress (0.934 ± 0.073 and 1.69 ± 0.159 MPa, for the non-SBC and SBC models, respectively) within the bone adjacent to the SBC. In addition, there was a positive correlation found between the diameter of the SBC and the resultant intra-osseous stress under load (p = 0.004).ConclusionsOur results provide insights into the mechanism by which SBC may accelerate OA, leading to greater pain and disability. Based on these findings, we feel that patient-derived FE models of the OA knee – utilizing in vivo imaging data – present a tremendous potential for monitoring joint mechanics under physiological loads.
Research Highlights
► Subchondral cysts (SBC) occur in the bones of the knee with advanced OA.
► Simulated SBC within finite element models of human knees lead to increased stress.
► Increased peri-cystic stress is likely the cause of cyst expansion in OA bones.
Journal: Bone - Volume 48, Issue 3, 1 March 2011, Pages 639–646