کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2780604 1153303 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T cells: Critical bone regulators in health and disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
T cells: Critical bone regulators in health and disease
چکیده انگلیسی

Postmenopausal osteoporosis and hyperparathyroidism are to two common forms of bone loss caused primarily by an expansion of the osteoclastic pool only partially compensated by a stimulation of bone formation. The intimate mechanisms by which estrogen deficiency and excessive production of PTH cause bone loss remain to be determined in part because in vitro studies do not provide the means to adequately reproduce the effects of ovx and PTH overproduction observed in vivo. This article examines the connection between T cells and bone in health and disease and reviews the evidence in favor of the hypothesis that T cells play an unexpected critical role in the mechanism of action of estrogen and PTH in bone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 47, Issue 3, September 2010, Pages 461–471
نویسندگان
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