کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2781978 1153340 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lithium use and the risk of fractures
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Lithium use and the risk of fractures
چکیده انگلیسی

A recent study reported a decreased risk of fractures among lithium users. We conducted a case–control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR] = 0.75, 95% confidence interval [CI] = 0.64–0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR = 1.35, 95% CI = 1.01–1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 40, Issue 5, May 2007, Pages 1252–1258
نویسندگان
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